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Effects of Hydroxyapatite Nanoparticles on Apoptosis and Invasion of Human Renal Cell Carcinoma 786-0 Cells |
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| Authors: | WANG Zhi-xin HOU Yi HAN Wei WANG Kai-chen GUO Bao-feng LIU Ying CHANG Xi-hua WANG Wei-hua NA Wan-li KONG Xiang-bo ZHAO Xu ZHANG Ling |
| Institution: | WANG Zhi-xin1,HOU Yi1,HAN Wei1,WANG Kai-chen1,GUO Bao-feng1,LIU Ying2,CHANG Xi-hua1,WANG Wei-hua1,NA Wan-li1,KONG Xiang-bo1,ZHAO Xu2 and ZHANG Ling3 1. Department of Urology,China-Japan Union Hospital of Jilin University,Changchun 130033,P. R. China,2. College of Chemistry,3. Department of Pathophysiology,Norman Bethune Medical School,Jilin University,Changchun 130021 |
| Abstract: | Renal cell carcinoma is the most common cancer of the kidney, and resistant to traditional therapies. The aim of this study is to investigate the effects of hydroxyapatite nanoparticles on human renal cell carcinoma 786-0 cells. Cell proliferation was assessed with an 3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide(MTT) staining kit. The apoptosis assay was assessed with an FITC Annexin V Apoptosis Detection Kit. Caspase-3 and caspase-12 were detected by immunocytochemical staining and semi-qua... |
| Keywords: | Renal cell carcinoma Hydroxyapatite nanoparticle Apoptosis Invasion |
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