Design, Synthesis and Biological Evaluation of 2-Aroyl-3-aryl-6,7-dihydro-5H-furo[3,2-g]chromen Derivatives as a Novel Series of Estrogen Receptor Modulators |
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| Authors: | WANG Shi-hui WANG Yan ZHU Yu-ying LIU Si-jie HAN Jian ZHOU Yi-fan LI Da-wei KOIRALA Diwa HU Chun . Key Laboratory of Structure-based Drug Design & Discovery Ministry of Education |
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| Affiliation: | WANG Shi-hui1,WANG Yan1,ZHU Yu-ying1,LIU Si-jie1,HAN Jian1,ZHOU Yi-fan1,LI Da-wei2,KOIRALA Diwa2 and HU Chun1 1. Key Laboratory of Structure-based Drug Design & Discovery,Ministry of Education,Department of Organic Chemistry,School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,P. R. China,2. School of Pharmacy,Shanghai Jiaotong University,Shanghai 200193 |
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| Abstract: | Based on the principles of the bioisosterism, combination of the active substructures of selective estrogen receptor modulators which are currently therapeutic agents available for the prevention and treatment of various es-trogen dependent diseases, and structural optimization, a novel series of 2-aroyl-3-aryl-6,7-dihydro-5H-furo[3,2-g]-chromen derivatives was designed as potent selective estrogen receptor modulators via molecular docking. The target compounds have been synthesized, and characterized by IR... |
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| Keywords: | Selective estrogen receptor modulator Docking Biological activity Heterocycle Furo[3 2-g]chromen |
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