sp C-H bond functionalization of methyl n-alkyl ketones [MeCOCnH2n+1 (n = 6-8)] as a novel method for the one-pot regioselective synthesis of ‘bifunctional alkanes’ with remote functional groups期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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sp C-H bond functionalization of methyl n-alkyl ketones [MeCOC_nH_2n+1 (n = 6-8)] as a novel method for the one-pot regioselective synthesis of ‘bifunctional alkanes’ with remote functional groups

Authors:	Irena S Akhrem Lyudmila V Afanas’evaNikolai D Kagramanov Pavel V Petrovskii

Institution:	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Street, Moscow 119991, Russia

Abstract:	Selective one-pot functionalization of methyl n-alkyl ketones, C_nH_2n+1COMe (n = 6-8) involving C-sp³-H bond cleavage with CO and various nucleophilic substrates ⁱPrOH, BuCH(Et)CH₂OH, CF₃CH₂OH, (CF₃)(Me)CHOH, H(CF₂)₂CH₂OH, HCCCH₂OH, furan, thiophene, and anisole] in the presence of the superelectrophilic system CBr₄·2AlBr₃ has been performed for the first time.

Keywords:	AVGREVYRKUVWRY-UHFFFAOYSA-N LVHMKIYZHHIKRO-UHFFFAOYSA-N ZNIJQUJBEYGCKF-UHFFFAOYSA-N LUTTYNKTVYBOAP-UHFFFAOYSA-N ODLLROAIBNGLPU-UHFFFAOYSA-N RPEUQIJIVGDOHU-UHFFFAOYSA-N MBPGPZIHJYSHFJ-UHFFFAOYSA-N RMIVANWKSKTBBE-UHFFFAOYSA-N BPAVUEFBDVOLSS-UHFFFAOYSA-N SNRQHPNFFUDQJD-UHFFFAOYSA-N ULVBJXRUTLVSBK-UHFFFAOYSA-N SWKHNOSKZCARQL-UHFFFAOYSA-N KRTPZBHKWMGNGX-UHFFFAOYSA-N
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