Monanchomycalins A and B, unusual guanidine alkaloids from the sponge Monanchora pulchra |
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| Authors: | Tatyana N Makarieva Ksenya M TabakmaherAlla G Guzii Vladimir A DenisenkoPavel S Dmitrenok Alexandra S KuzmichHyi-Seung Lee Valentin A Stonik |
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| Institution: | a G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok-22, Prospect 100-let Vladivostoku 159, Russia
b Korea Ocean Research and Development Institute, Marine Natural Products Laboratory, Ansan 426-744, Republic of Korea |
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| Abstract: | New pentacyclic guanidine alkaloids, monanchomycalins A (1) and B (2) were isolated from the marine sponge, Monanchora pulchra and their structures elucidated using NMR, HRMALDI-TOF-MS, and HRESI MS, as well as by chemical transformations of 1. Compounds 1 and 2 exhibited potent cytotoxic activities against HL-60 human leukemia cells with IC50 values of 120 and 140 nM, respectively. |
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| Keywords: | Pentacyclic guanidine alkaloids Monanchomycalins Spermidine Marine sponge Monanchora pulchra |
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