Abstract: | Five new 6‐polyhaloacylnorkhellins were synthesized in high yields from diethoxymethyl acetate and the condensation products of khellinone with RFCO2Et and CCl3COCl. Reaction of 6‐polyfluoroacylnorkhellins with primary aromatic amines yielded 6‐(arylaminomethylene)‐7‐hydroxy‐4,9‐dimethoxy‐7‐(polyfluoroalkyl)furo3,2‐g]chroman‐5‐ones. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:99–103, 2006; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20174 |