| Abstract: | We report the preparation of four diastereoisomeric pairs of ethyl {(3‐hydroxypropyl)‐ amino](aryl)methyl}phenylphosphinates. In two cases, the phosphinates were transformed to 1,4,2‐oxazaphosphepane heterocycles through one‐pot intramolecular esterification. The analogous reaction with formaldehyde gave the six‐membered ethyl (1,3‐oxazinan‐3‐ylmethyl)phenylphosphinate, which could be transformed in a posterior reaction to the corresponding aminomethanephosphinic acid. The new compounds were characterized by IR, 1H, 13C, and 31P NMR. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:81–87, 2006; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20179 |
