An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines |
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| Authors: | Romy E. MartinMarta E. Polomska Lindsay T. ByrneScott G. Stewart |
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| Affiliation: | School of Biomedical, Biomolecular and Chemical Science, University of Western Australia, 35 Stirling Hwy, Crawley, 6009 WA, Australia |
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| Abstract: | Herein we describe the efficient stereoselective preparation of C8 substituted indolizidines bearing a 6-methylene group, from the chiral pool starting material l-proline. This synthesis, employing a Tsuji-Trost reaction as the key step, represents a potentially, efficient route to pumiliotoxin natural product epimers. |
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| Keywords: | Indolizidines Intramolecular Tsuji-Trost reaction Allylation Pumiliotoxins |
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