A ligand-free copper(I) oxide catalyzed strategy for the N-arylation of azoles in water |
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| Authors: | Fui-Fong YongYong-Chua Teo Siew-Hoon TayBryan Yong-Hao Tan Kim-Huat Lim |
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| Institution: | Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore 637616, Singapore |
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| Abstract: | A simple and practical protocol has been developed for the cross-coupling of azoles and aryl iodides under ligand-free copper(I) oxide catalyzed conditions in water. The protocol uses tetrabutylammonium bromide (TBAB) as the phase-transfer catalyst, and water as the solvent, and shows good tolerance towards various functional groups. |
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