Performance characteristics of Mammalian Cell Culture process operating continuously with protein-free medium |
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Authors: | R Bliem R Oakley K Matsuoka V Taiariol |
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Institution: | Bio-Response, Inc., Hayward, CA 94545. |
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Abstract: | In this communication we briefly describe a continuous industrial process for the production of Tissue Plasminogen Activator (tPA), operating with a standard, basal medium (DME/F12). Process data of two culture runs has been chosen to present a performance profile over a production period of more than 3 mo. Developmental aspects of glucose utilization (as a process parameter) are briefly discussed. |
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