Amine and ammonium functionalization of chloromethylsilane-ended dendrimers. Antimicrobial activity studies |
| |
Authors: | Ortega Paula Copa-Patiño Jose Luis Muñoz-Fernandez Ma Angeles Soliveri Juan Gomez Rafael de la Mata F Javier |
| |
Institution: | Departamento de Química Inorgánica, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Spain. |
| |
Abstract: | Novel amine- and ammonium-terminated carbosilane dendrimers of type G(n)-Si{CH(2)O-(C(6)H(4))-3-NMe(2)}](x) or G(n)-Si{CH(2)O-(C(6)H(4))-3-NMe(3)(+)I(-)}](x) have been synthesized and characterized up to second generation by phenolysis of (chloromethyl)silyl-terminated dendrimers with 3-dimethylamine phenol and subsequent quaternization with methyl iodide. Quaternized carbosilane dendrimers are stable in protic solvents and can be solubilised in water after the addition of less than 1% of dimethyl sulfoxide. A study of the antimicrobial activity of these cationic dendrimers of first and second generation against both gram-positive and gram-negative bacteria is also described. The results obtained demonstrate that the new ammonium-terminated carbosilane dendrimers can be considered as multivalent biocides. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |