| 三七内生真菌Talaromyces Purpureogenus中2个Drimane倍半萜绝对构型的鉴定 |
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| 引用本文： | 张冰洋,马洋洋,郭华,朱华结,李婉.三七内生真菌Talaromyces Purpureogenus中2个Drimane倍半萜绝对构型的鉴定[J].高等学校化学学报,2017,38(6). |
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| 作者姓名： | 张冰洋 马洋洋 郭华 朱华结 李婉 |
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| 作者单位： | 药物化学与分子诊断教育部重点实验室,河北省药物质量分析控制重点实验室,河北大学药学院,保定 071002 |
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| 基金项目： | 河北大学人才引进项目、 保定市科技支撑项目，河北大学超算中心项目资助，the Talent Researcher Program of Hebei University |
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| 摘 要： | 采用经典柱色谱法从三七内生真菌Talaromyces purpureogenus中分离得到2个化合物(1和2),经核磁共振波谱和质谱确认其结构均为Drimane倍半萜.通过量子化学计算比较电子圆二色谱(ECD)、旋光(OR)与实验值的方法鉴定了化合物1和2的绝对构型.生物活性测试结果显示,化合物1对大肠杆菌(E.coli)具有一定的抗菌活性(MIC=25μmol/L).
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| 关 键 词： | 三七内生真菌 电子圆二色谱 绝对构型 抗菌活性 |
Absolute Configuration Determination of Two Drimane Sesquiterpenoids from the Endophytic Fungi Talaromyces Purpureogenus of Panax notoginseng |
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| ZHANG Bingyang,MA Yangyang,GUO Hua,ZHU Huajie,LI Wan.Absolute Configuration Determination of Two Drimane Sesquiterpenoids from the Endophytic Fungi Talaromyces Purpureogenus of Panax notoginseng[J].Chemical Research In Chinese Universities,2017,38(6). |
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| Authors: | ZHANG Bingyang MA Yangyang GUO Hua ZHU Huajie LI Wan |
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| Abstract: | Two drimane sesquiterpenoids(1, 2) were isolated from cultures of the fungus Talaromyces purpureogenus.The planar structures were well established by NMR and mass spectrometry, and the absolute configurations(AC) were determined by comparing experimental electronic circular dichroism(ECD) and optical rotation(OR) of compounds 1 and 2 with the calculated ECD and OR data using quantum methods.Compounds 1 and 2 were evaluated for antibacterial activities against four spices of pathogenic bacteria, and the results showed that compound 1 had weak antibacterial activities against Escherichia coli(MIC=25 μmol/L). |
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| Keywords: | Talaromyces purpureogenus Electroic circalar dichroism(ECD) Absolute configuration Antibacterial activity |
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