| 胰岛素联合沙格列汀降糖疗效及安全性的研究 |
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| 引用本文： | 吕凌波,简玉香,陈苑波. 胰岛素联合沙格列汀降糖疗效及安全性的研究[J]. 广东微量元素科学, 2017, 24(5). DOI: 10.3969/j.issn.1006-446X.2017.05.006 |
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| 作者姓名： | 吕凌波 简玉香 陈苑波 |
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| 作者单位： | 深圳市第二人民医院,广东 深圳,518000 |
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| 基金项目： | 201506020深圳市卫人委 |
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| 摘 要： | 目的评估胰岛素联合沙格列汀治疗2型糖尿病的有效性和安全性。方法回顾性对照研究50例2型糖尿病患者胰岛素加用沙格列汀或阿卡波糖治疗(48±8)周后血糖水平和血糖波动等指标的变化。结果治疗(48±8)周后,两组血糖、Hb A1c、MAGE均明显下降(P均≤0.001),其中沙格列汀组MAGE的降幅明显大于阿卡波糖组(P=0.024),胃肠道不良反应发生率显著低于阿卡波糖组。结论沙格列汀联合胰岛素具有更强的控制血糖波动的疗效,胃肠道不良反应发生率更低。
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| 关 键 词： | 2型糖尿病 沙格列汀 阿卡波糖 血糖波动 |
Study on Hypoglycemic Effect and Safety of Insulin Combined with Shah Glenn Dean |
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| LU Lingbo,JIAN Yuxiang,CHEN Yuanbo. Study on Hypoglycemic Effect and Safety of Insulin Combined with Shah Glenn Dean[J]. Trace Elements Science, 2017, 24(5). DOI: 10.3969/j.issn.1006-446X.2017.05.006 |
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| Authors: | LU Lingbo JIAN Yuxiang CHEN Yuanbo |
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| Abstract: | Objective To assess the efficacy and safety of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes(T2DM) on basic of insulin.Methods 50 patients with poorly controlled T2DM on basic of insulin were added on saxagliptin or acarbose for (48±8) weeks.Retrospective control studies change of plasma glucose,HbA1c,MAGE and so on.Results After treatment for (48±8) weeks,the plasma glucose,HbA1c and MAGE decreased significantly in both groups(all P≤0.001).It shows more remarkable decrease in MAGE and less gastrointestinal symptoms in saxagliptin group than those of acarbose group(P=0.024).Conclusion Saxagliptin-insulin has similar effect on glucose control with acarbose-insulin in patients with T2DM,and more improvement in glucose fluctuations and lower gastrointestinal side effects than the latter. |
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| Keywords: | type 2 diabetes mellitus saxagliptin acarbose glucose fluctuations |
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