HPV在宫颈炎、宫颈癌前病变、宫颈癌中的检测及其临床意义研究

目的研究并探讨人乳头状瘤病毒(human papillomavirus,简称HPV)在宫颈炎、宫颈癌前病变、宫颈癌中的检测价值及临床意义。方法选取菏泽市妇幼保健院2014年1月—2016年12月期间收治的120例慢性宫颈炎患者、90例宫颈癌前病变患者、60例宫颈癌患者作为研究对象,分别设置为宫颈炎组、癌前病变组、宫颈癌组,并将癌前病变组分为CIN Ⅰ级、CIN Ⅱ级、CIN Ⅲ级,所有患者均接受HPV检测,比较其HPV阳性率、HPV DNA负荷载量、HPV感染持续时间,计算HPV感染持续时间、HPV DNA负荷载量与宫颈癌发生的相关性。结果宫颈炎组、癌前病变组、宫颈癌组的HPV阳性率、HPV DNA负荷载量、HPV感染持续时间比较,差异均具有统计学意义(P0.05),从高至低依次为宫颈癌组、癌前病变组、宫颈炎组,且不同分级宫颈癌前病变患者的HPV DNA负荷载量、HPV感染持续时间均存在显著差异(P0.05);经相关性分析,HPV感染持续时间、HPV DNA负荷载量均与宫颈癌的发生密切相关,呈正相关。结论HPV感染可能参与到宫颈癌前病变、宫颈癌的发生、发展中,开展HPV检测可对宫颈癌前病变、宫颈癌进行筛查,有利于宫颈癌的防治。

HPV in Cervicitis,Cervical Cancer Lesion Before,Cervical Cancer Detection and Significance of the Research

Objective To study and discuss human papilloma virus(human papillomavirus,HPV)in cervical disease,cervical cancer lesion before,testing value and clinical significance of cervical cancer.Methods From January 2014 to December 2016 during the selection of the phase in our hospital,admitted during the period of 120 cases of chronic cervicitis patients,90 patients with cervical cancer lesion before,60 cases of cervical cancer patients as the research object,set to cervicitis groups respectively,the precancerous lesions,cervical cancer,precancerous lesion group and then divided into CIN I,CIN II,CIN level III,all patients were tested for HPV,compare the HPV positive loads,HPV infection,HPV DNA load duration,calculate the duration of HPV infection,HPV DNA load capacity and the correlation of cervical cancer.Results Cervicitis groups and precancerous lesions,cervical cancer HPV positive rate of loads,HPV infection,HPV DNA load duration,the differences were statistically significant(P＜0.05),from high to low in turn for cervical cancer and precancerous lesion group,cervicitis groups,and different classification of patients with cervical cancer lesion before HPV DNA load capacity,HPV infection duration were significant differences(P＜0.05);Through correlation analysis,duration of HPV infection,HPV DNA load capacity are closely related with the occurrence of cervical cancer,were positively correlated.Conclusion HPV infection may be involved in the occurrence and development of cervical cancer lesion before,cervical cancer,HPV detection for cervical cancer lesion before,cervical cancer screening,is advantageous to the prevention and treatment of cervical cancer.