Copper-catalyzed cycloisomerizations of 5-en-1-yn-3-ols |
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| Authors: | Fehr Charles Farris Iris Sommer Horst |
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| Institution: | Firmenich SA, Corporate R&D Division, P.O. Box 239, CH-1211 Geneva, Switzerland. charles.fehr@firmenich.com |
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| Abstract: | reaction: see text] The Cu(I)-catalyzed cycloisomerization of tertiary 5-en-1-yn-3-ols with an 1,2-alkyl shift affords stereoselectively tri- and tetracyclic compounds of high molecular complexity. These results are in agreement with a mechanism in which the cyclopropanation precedes the rearrangement. |
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