A concise total synthesis of naamidine A |
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| Authors: | Aberle Nicholas S Lessene Guillaume Watson Keith G |
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| Institution: | Medicinal Chemistry Group, The Walter and Eliza Hall Institute of Medical Research, Biotechnology Centre, 4 Research Avenue, Bundoora 3086, Victoria, Australia. |
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| Abstract: | reaction: see text]. A total synthesis of naamidine A is reported. Key benefits of the described pathway include its brevity, its synthetic ease, and its flexibility with respect to the preparation of analogues. Formation of the 2-aminoimidazole core is achieved by condensation of the appropriate alpha-aminoketone with cyanamide. |
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