Inhibition of prefrontal protein synthesis following recall does not disrupt memory for trace fear conditioning |
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Authors: | Sonja Blum Jason D Runyan Pramod K Dash |
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Affiliation: | (1) The Vivian L. Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas, Houston, Texas 77225, USA |
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Abstract: | Background The extent of similarity between consolidation and reconsolidation is not yet fully understood. One of the differences noted is that not every brain region involved in consolidation exhibits reconsolidation. In trace fear conditioning, the hippocampus and the medial prefrontal cortex (mPFC) are required for consolidation of long-term memory. We have previously demonstrated that trace fear memory is susceptible to infusion of the protein synthesis inhibitor anisomycin into the hippocampus following recall. In the present study, we examine whether protein synthesis inhibition in the mPFC following recall similarly results in the observation of reconsolidation of trace fear memory. |
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