Nonlinear pressure dependence of the interaction potential of dense protein solutions |
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Authors: | Schroer Martin A Markgraf Jonas Wieland D C Florian Sahle Christoph J Möller Johannes Paulus Michael Tolan Metin Winter Roland |
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Institution: | Faculty of Physics/DELTA, TU Dortmund, Maria-Goeppert-Mayer-Str. 2, 44227 Dortmund, Germany. |
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Abstract: | The influence of pressure on the structure and protein-protein interaction potential of dense protein solutions was studied and analyzed using small-angle x-ray scattering in combination with a liquid state theoretical approach. The structural as well as the interaction parameters of dense lysozyme solutions are affected by pressure in a nonlinear way. The structural properties of water lead to a modification of the protein-protein interactions below 4?kbar, which might have significant consequences for the stability of proteins in extreme natural environments. |
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