The intramolecular allenolate rauhut-currier reaction |
| |
Authors: | James A Mackay Zachary C Landis Stephen E Motika Margaret H Kench |
| |
Institution: | Department of Chemistry and Biochemistry, Elizabethtown College , 1 Alpha Drive, Elizabethtown, Pennsylvania 17022, United States. |
| |
Abstract: | An intramolecular Rauhut-Currier reaction utilizing alkynoates as the initial conjugate acceptor affords densely functionalized 5- and 6-membered rings from ynoate-enoate, ynoate-enenitrile, and alkynyl sulfone-enenitrile substrates. Trialkylphosphines catalyze the reaction, and TMSCN serves as a pronucelophile to effect turnover of the catalyst and the formation of a second C-C bond. Because of the highly electrophilic alkyne acceptor, this reaction yields products that cannot be easily accessed from the traditional Rauhut-Currier reaction. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|