| 蛋氨酸亚砜还原酶的结构特征及与神经退行性疾病的关系 |
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| 引用本文： | 王超,姜亮,王勇,宋国丽,刘琼,杨思林,宋云,倪嘉缵. 蛋氨酸亚砜还原酶的结构特征及与神经退行性疾病的关系[J]. 中国科学:化学, 2014, 0(4): 586-600 |
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| 作者姓名： | 王超 姜亮 王勇 宋国丽 刘琼 杨思林 宋云 倪嘉缵 |
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| 作者单位： | [1]中国科学院长春应用化学研究所,长春130022 [2]深圳大学生命科学学院,深圳518060 [3]中国科学院大学,北京100049 [4]安徽省华信生物药业股份有限公司,界首236500 |
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| 基金项目： | 国家自然科学基金(31070731,21271131);广东省自然科学基金(10151806001000023);深圳市科技研发资金基础研究计划项目(JC201005280537A,JCYJ20120817163755064)资助 |
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| 摘 要： | 蛋氨酸易被氧化为蛋氨酸亚砜,使生物体中氧化还原平衡失调,诱发各种疾病.蛋氨酸亚砜还原酶(Msrs)能将蛋氨酸亚砜还原成蛋氨酸,恢复蛋白的结构与功能,对调控多种氧化应激相关疾病具有重要作用.本文结合本课题组的研究结果,介绍了Msrs的分类进化、结构特征、催化机理和基因工程表达;综述了Msrs与衰老、帕金森病和阿尔茨海默病的关系,以探讨有关Msrs研究的发展方向和应用前景.
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| 关 键 词： | 蛋氨酸亚砜还原酶 硒蛋白 衰老 帕金森病 阿尔茨海默病 |
Characteristics of methionine sulfoxide reductases structure and relationship with neurodegenerative diseases |
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| WANG Chao,＇,＇,JIANG Liang,WANG Yong,SONG GuoLi,LIU Qiong,.,YANG SiLin,SONG Yun,NI JiaZuan. Characteristics of methionine sulfoxide reductases structure and relationship with neurodegenerative diseases[J]. Scientia Sinica Chimica, 2014, 0(4): 586-600 |
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| Authors: | WANG Chao ＇ ＇ JIANG Liang WANG Yong SONG GuoLi LIU Qiong . YANG SiLin SONG Yun NI JiaZuan |
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| Affiliation: | 1＇2. 1 Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China 2 College of Life Sciences, Shenzhen University, Shenzhen 518060, China 3 University of Chinese Academy of Sciences, Beijing 100049, China 4 Huaxin Bio-Pharmaceutical Co., Ltd, Jieshou 236500, China |
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| Abstract: | Methionine can be oxidized to methionine sulfoxide, causing redox imbalance in vivo and inducing many diseases. Methionine sulfoxide reductases （Msrs） can reduce methionine sulfoxide to methionine, thus renovate protein structure and function, and prevent oxidative stress-relevant diseases. This review mainly includes the classification and evolution of Msrs, the protein structural feature and catalytic mechanism, and protein expression via genetic engineering. It summarizes recent development in Msrs and aging or Parkinson＇s disease or Alzheimer＇s disease, as well as our own results. The prospect of Msrs research is also discussed in this paper. |
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| Keywords: | methoine sulfoxide reductase （Msrs） selenoprotein aging Parkinson＇s disease Alzheimer＇s disease |
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