X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG) |
| |
| Authors: | Ferraroni Marta Bazzicalupi Carla Bilia Anna Rita Gratteri Paola |
| |
| Institution: | Department of Chemistry Ugo Schiff, University of Firenze, Via della Lastruccia 3-13, I-50019 Sesto Fiorentino, Firenze, Italy. |
| |
| Abstract: | The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)(2) DNA sequence were obtained by X-ray diffraction analysis at 2.3 ? resolution. Both drugs join the end of two "two-molecules" DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)(2) DNA in its iminium form. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
