Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex |
| |
| Authors: | Lu Yu-Jing Yan Siu-Cheong Chan Fung-Yi Zou Lan Chung Wai-Hong Wong Wing-Leung Qiu Bin Sun Ning Chan Pak-Ho Huang Zhi-Shu Gu Lian-Quan Wong Kwok-Yin |
| |
| Institution: | Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. |
| |
| Abstract: | A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective response of the fluorescent probe arises from end-stack binding to G-quadruplex. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
