DOTASQ as a prototype of nature-inspired G-quadruplex ligand |
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| Authors: | Stefan Loic Guédin Aurore Amrane Samir Smith Nicole Denat Franck Mergny Jean-Louis Monchaud David |
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| Institution: | Institut de Chimie Moléculaire, CNRS UMR5260, Université de Bourgogne, Dijon, France. |
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| Abstract: | DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand). |
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