TBAF-catalysed silver oxide-mediated cross-coupling of functional trimethysilylpyridines: access to arylpyridines and bihetaryl compounds |
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| Authors: | Louërat Frédéric Tye Heather Napier Spencer Garrigou Michael Whittaker Mark Gros Philippe C |
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| Affiliation: | Groupe SOR, SRSMC, CNRS, Nancy Université, Boulevard des Aiguillettes, 54506, Vandoeuvre-Lès-Nancy, France. |
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| Abstract: | The concomitant use of silver oxide and catalytic amount of TBAF allowed the efficient and chemoselective coupling of readily available 4-chloro- and 4-methyl-2-trimethyl-silyl-pyridines with heteroaromatic and aromatic halides. Based on control experiments, a mechanism involving the formation of a pyridylsilver intermediate and TBAF recycling is postulated. |
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