中等严重程度冠状动脉病变模型的血流动力学参数分析

基于中等严重程度冠状动脉病变模型,应用流固耦合方法数值研究了中等严重程度面积狭窄率(AS=50%,65%,75%)和病变长度(LL= 0 mm,15 mm,20 mm) 对血流动力学参数的影响.研究发现:随着AS与LL的增大,病变血管分支的壁面剪应力变化愈加剧烈,狭窄段下游的壁面剪应力值逐渐降低,狭窄段下游回流区的长度呈"S"型增长,模型最大剪切速率呈抛物线型增长, 压力分布曲线显著下降.血流动力学参数结果表明, 中等严重程度面积狭窄率和病变长度均是可能引发血栓的因素,临床上应予以重视. 

HEMODYNAMIC PARAMETERS ANALYSIS FOR CORONARY ARTERY STENOSIS OF INTERMEDIATE SEVERITY MODEL

This paper studies the e ects of coronary artery stenosis of intermediate severity on atherosclerotic process using fluid-structure interaction method. The aim of the study was to analysis the impact of area stenosis (AS = 50%, 65%, 75%) and lesion length (LL = 10 mm, 15 mm, 20 mm) on hemodynamic parameters. Through numerical simulations, it is found that a big margin of oscillating wall shear stress was generated in the branch of coronary artery stenosis and a low wall shear stress was generated in the downstream of stenosis when area stenosis and lesion length increase. The length of the recirculation zone downstream of the stenosis will present with S-shaped growth and the maximum shear rate will grow as parabolic at the same time. In addition, stenosis can bring about a significant decline in pressure. Hemodynamic parameters results show that, intermediate severity area stenosis and lesion length are the factors may cause thrombosis, clinical should attach importance to it.