Building Blocks for the Synthesis of Maytansinoids. Preliminary Communication |
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| Authors: | Erwin Gtschi Fernand Schneider Hans Wagner Karl Bernauer |
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| Institution: | Erwin Götschi,Fernand Schneider,Hans Wagner,Karl Bernauer |
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| Abstract: | The dienal 14 and the ketone 19 , both potential building blocks of maytansinoids, were synthesized starting from ethyl vanillate ( 2 ) via the aldehyde 9 . It could be shown in a preliminary experiment that the dienal 14 can be coupled with 2-lithio-1,3-dithiane to afford compound 16 which exhibits the correctly substituted aromatic part of maytansine as well as its C(9) to C(15) moiety. |
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