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Synthesis of <Emphasis Type="Italic">tert</Emphasis>-butyl 1-(5,8-dioxohexahydro-[1,3]thiazolo[3,4-<Emphasis Type="Italic">a</Emphasis>]pyrazin-3-yl)ethylcarbamate |
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| Authors: | Y Liu X Liu W Sun H Fang M Li W Xu |
| Institution: | 1. Shandong Polytechnic University, 3501, Daxue Road, Jinan, 250353, Shandong, China 2. Qilu Hospital, Shandong University, 107, West Wenhua Road, Jinan, 250012, Shandong, China 3. School of Pharmaceutical Sciences, Shandong University, 44, West Wenhua Road, Jinan, 250012, Shandong, China |
| Abstract: | Two diastereomers of the previously unknown diketopiperazines tert-butyl 1-(5,8-dioxohexahydro-1,3]thiazolo3,4-a]pyrazin-3-yl)ethylcarbamate were synthesized and separated by column chro-matography on silica gel. During the cultivation of the crystal of one of compounds, the product was oxidized to corresponding tert-butyl 1-(5,8-dioxo-5,6,7,8-tetrahydro1,3]thiazolo3,4-a]pyrazin-3-yl)-ethylcarbamate. The X-ray crystal structure of the latter was established. |
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