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A new C2-symmetric chiral bisphosphine ligand containing a bioxazole backbone: highly enantioselective hydrosilylation of ketones
Authors:Sang-gi Lee  Chung Woo Lim  Choong Eui Song  In O Kim
Institution:

Division of Applied Science, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea

Abstract:C2-Symmetric (4S,4′S)-2,2′-bis(o-diphenylphosphinophenyl)-4,4′,5,5′-tetrahydro-4,4′-bi(1,3-oxazole) (1, Phos-Biox) has been designed and synthesized as a chiral ligand for metal-catalyzed reactions. The Phos-Biox 1 was found to be an efficient ligand for rhodium(I)-catalyzed asymmetric reduction of prochiral acetophenones with diphenylsilane to give optically active secondary alcohols of up to 97% ee.
Keywords:
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