镧系发光材料用于生物成像的研究进展

镧系元素因其特殊的4f电子层结构而具有优异的光谱特性，如尖锐的线状谱带和相对较长的激发态寿命，这大大提高了其光学成像性能，是一类新型的成像元素.但其电子跃迁几率低，表现出较差的发光强度及较低的吸光效率，这对镧系发光材料作为生物成像探针的发展有一定的阻碍.近些年，研究者们通过设计镧系材料组成与结构，对其发光性能进行调控，使其成像性能得到了极大的提升.该文分别综述了镧系配合物、镧系纳米粒子作为成像探针的发光原理、材料类型及生物应用.

Recent advance of lanthanide luminescent materials in biological imaging

Due to the special structure of 4f electron layer, lanthanides have excellent spectral characteristics, such as sharp linear bands and relatively long excited state lifetime, which greatly improves their optical imaging performance and makes them a new type of imaging elements. However, their low electron transition probability, low light absorption efficiency, and low luminescence intensity have hindered the development of lanthanide luminescent materials as biological imaging probes. In recent years, numerous researchers have tried to resolve this problem through designing luminescence materials based on lanthanides elements. This article summarizes the recent advance in the luminant mechanism, material types, and biological applications of lanthanide coordination complexes and lanthanide nanoparticles as bioluminescence imaging agents.