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Flow Cytometry Analysis of |
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| Authors: | T. A. Bogush I. A. Mamichev Iu. P. Borisenko E. A. Bogush N. O. Vichljantseva V. Ju. Kirsanov |
| Affiliation: | 1.Blokhin National Medical Research Center of Oncology,Ministry of Healthcare of the Russian Federation,Moscow,Russia;2.Department of Fundamental Medicine,Moscow State University,Moscow,Russia;3.Sechenov First Medical University,Ministry of Healthcare of the Russian Federation,Moscow,Russia |
| Abstract: | The proportion of diploid cells in the G0/G1 cell cycle phases was estimated by flow cytometry in 60 samples of stage III serous ovarian cancer tissue. The tumor tissue shows considerable heterogeneity with regard to the content of this tissue fraction, which ranged from 27 to 95% with a median of 73%. Statistically significant differences in the size of this fraction were identified by comparing tumor subgroups sensitive and resistant to first-line platinum-taxane chemotherapy. Predictive significance of the G0/G1 fraction was concluded and quantitative evaluation of this fraction is recommended for clinical use. |
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