Rhodium-catalyzed asymmetric arylative ring opening of bicyclic hydrazines

The development of a novel asymmetric ring opening of bi- and polycyclic hydrazines with aryl organometallic reagents is presented. The application of this reaction to the most simple bicyclic hydrazine 1a gives a straightforward regio- and diastereoselective access to synthetically useful trans 3,4-disubstituted hydrazinocyclopentenes in an enantioenriched form.