Synthesis of unsymmetrical diarylureas via Pd-catalyzed C-N cross-coupling reactions |
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| Authors: | Breitler Simon Oldenhuis Nathan J Fors Brett P Buchwald Stephen L |
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| Affiliation: | Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. |
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| Abstract: | A facile synthesis of unsymmetrical N,N'-diarylureas is described. The utilization of the Pd-catalyzed arylation of ureas enables the synthesis of an array of diarylureas in good to excellent yields from benzylurea via a one-pot arylation-deprotection protocol, followed by a second arylation. |
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