Continuous production of antibiotics in an airlift fermentor utilizing a transverse magnetic field |
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Authors: | Zakaria Al-Qodah |
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Institution: | (1) Department of Chemical Engineering, Amman Colleg for Engineering Technology, Al-Balqa Applied University, PO Box 340558, Marka, Amman, Jordan |
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Abstract: | In this study, a series of experiments was conducted to demonstrate the feasibility of continuous production of penicillin
antibiotic using a three-phase magneto airlift fermentor with immobilized Penicillium chrysogenum. The fermentation processes were carried out in a 2.4-L external loop airlift utilizing a transverse magnetic field. It was
found that the application of the magnetic field to a bed of ferromagnetic beads affects both the hydrodynamics of the reactor
and the rate of the bioconversion process occurring inside it. One hundred hours after startup, the maximum penicillin concentration
increased 48% as the magnetic field intensity increased from 0 to 35 mT, owing to the increased residence time of the substrate
in the riser and the positive effect of the magnetic field on the effective fluid-solid interfacial area. In addition, the
detached biomass concentration in the liquid phase was found to be only 5% of the immobilized biomass, owing to low shear
levels and the absence of friction among the solid-phase particles. |
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Keywords: | Magnetic stabilization magneto airlift reactors magnetic field penicillin production penicillium chrysogenum |
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