Eco-friendly synthesis of 1,4-benzodiazepine-2,5-diones in the ionic liquid [bmim]Br |
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Authors: | Khosrow Jadidi Ramin Ghahremanzadeh Davoud Asgari Parisa Eslami Hamid Arvin-Nezhad |
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Affiliation: | (1) Department of Chemistry, Shahid Beheshti University, Tehran, Iran;(2) Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
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Abstract: | The green reaction of isatoic anhydrides with α-amino acids in presence of the ionic liquid 1-butyl-3-methylimidazolium bromide afforded 1,4-benzodiazepine-2,5-diones in excellent yields in absence of a catalyst. The reaction workup is simple and the ionic liquid was easily recovered from the reaction and reused. The methodology was quite general and a range of cyclic and acyclic α-amino acids were examined to produce 1,4-benzodiazepine-2,5-diones. Correspondence: Khosrow Jadidi, Department of Chemistry, Shahid Beheshti University, PO Box 1983963113, Tehran, Iran. |
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Keywords: | 1,4-Benzodiazepine-2,5-diones α -Amino acids Ionic liquid Isatoic anhydride. |
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