Reaction Of 3-Nitro-1,2,4-triazolederivatives with Alkylating Agents. 1. Alkylation in the Presence of Alkali |
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| Authors: | G T Sukhanov A Yu Lukin |
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| Institution: | (1) Institute of Problems of Chemical Energy Technology, Siberian Branch, Russian Academy of Sciences, Biisk, 659322, Russia;(2) Altai Federal Industrial Science Center, Federal State Unitary Enterprise, Biisk, 659322, Russia |
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| Abstract: | Alkylation of 3-nitro-1,2,4-triazole and 5-methyl-3-nitro-1,2,4-triazole with dialkyl sulfates or alkyl halides in the presence
of alkali proceeds with a low selectivity for the alkylating agent with the formation of two regioisomers at the N(1) and N(2) atoms of the heterocycle. Depending on the reaction conditions the proportion of the N(2) isomer was 14.6-33.8%.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1020–1025, July, 2005. |
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| Keywords: | 1-alkyl-3-nitro-1 2 4-triazoles 1-alkyl-5-nitro-1 2 4-triazoles 3-nitro-1 2 4-triazoles alkylation regioselectivity |
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