| Elucidation of O-Phosphoryl and N-Phosphoryl Amino Acids by Electrospray Ionization Tandem Mass Spectrometry |
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| 引用本文： | 张建臣 曹书霞 徐军 廖新成 赵玉芬. Elucidation of O-Phosphoryl and N-Phosphoryl Amino Acids by Electrospray Ionization Tandem Mass Spectrometry[J]. 中国化学, 2004, 22(8): 870-873. DOI: 10.1002/cjoc.20040220822 |
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| 作者姓名： | 张建臣 曹书霞 徐军 廖新成 赵玉芬 |
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| 作者单位： | [1]TheKeyLaboratoryofChemicalBiology,DepartmentofChemistry,ZhengzhouUniversity,Zhengzhou,Henan450052,China [2]TheKeyLaboratoryforBioorganicPhosphorusChemistryandChemicalBiology,MinistryofEducation,DepartmentofChemistry,SchoolofLifeSciencesandEngineering,TsinghuaUniversity,Beijing100084,China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China (No. 20175026). |
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| 摘 要： | Mass spectroscopic characteristics of phosphoryl amino acids were studied in detail by positive and negative electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem mass spectrometry (MS/MS). Besides N-diisopropyloxyphosphoryl amino acids (N-DIPP-AA), O-phospho- and O-diisopropyloxyphosphoryl amino acids (O-DIPP-AA) were studied and compared to N-DIPP-AA. The fragmentation pathways of [M H]^ ,[M Na]^ and [M-H]^- ions of phosphoryl amino acids were summarized. In addition to several similar patterns, each of them showed its characteristic fragmention.
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| 关 键 词： | O-磷酰基氨基酸 N-磷酰基氨基酸 电喷雾串联质谱 N-二异丙基氧磷酰基氨基酸 |
Elucidation of O-Phosphoryl and N-Phosphoryl Amino Acids by Electrospray Ionization Tandem Mass Spectrometry |
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| Jian‐Chen Zhang,Shu‐Xia Cao,Jun Xu,Xin‐Cheng Liao,Yu‐Fen Zhao. Elucidation of O-Phosphoryl and N-Phosphoryl Amino Acids by Electrospray Ionization Tandem Mass Spectrometry[J]. Chinese Journal of Chemistry, 2004, 22(8): 870-873. DOI: 10.1002/cjoc.20040220822 |
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| Authors: | Jian‐Chen Zhang Shu‐Xia Cao Jun Xu Xin‐Cheng Liao Yu‐Fen Zhao |
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| Abstract: | Mass spectroscopic characteristics of phosphoryl amino acids were studied in detail by positive and negative electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem mass spectrometry (MS/MS). Be- sides N-diisopropyloxyphosphoryl amino acids (N-DIPP-AA), O-phospho- and O-diisopropyloxyphosphoryl amino acids (O-DIPP-AA) were studied and compared to N-DIPP-AA. The fragmentation pathways of [M+H]+, [M+Na]+ and [M-H]- ions of phosphoryl amino acids were summarized. In addition to several similar patterns, each of them showed its characteristic fragmention. |
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| Keywords: | N-phosphoryl amino acid O-phosphoryl amino acid electrospray ionization tandem mass spec- trometry |
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