Mathematical structure of chromatographic optimization based on information theory: I. Effect of mobile phase composition on precision |
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Authors: | Y Hayashi R Matsuda |
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Institution: | (1) National Institute of Hygienic Sciences, 1-18-1, Kamiyoga, 158 Setagaya, Tokyo, Japan |
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Abstract: | Summary The influence of mobile phase composition X on the precision of liquid-chromatographic analysis is interpreted in terms of the derivate of the mutual information for peak j with respect to X, dj/dX. The sign and magnitude of dj/dX depend on the operational conditions of X or on the details of chromatograms (e.g., resolutions Rs), but dj/dX always indicates the direction of X toward more information j. The sensitivity function sj(=1/(kj+1)) is examined on the basis of information theory. Optimization is formulated as a nonlinear programming problem. |
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Keywords: | Chromatography general Optimization Information theory Kalman filter |
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