Pd-catalyzed carboetherification of beta,gamma-unsaturated oximes: a novel approach to Delta2-isoxazolines |
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| Authors: | Jiang Dahong Peng Jinsong Chen Yuanwei |
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| Affiliation: | Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China. |
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| Abstract: | A novel route to the synthesis of Delta2-isoxazoline derivatives is described. Reaction of beta,gamma-unsaturated oximes with aryl bromides via palladium-catalyzed carboetherification affords 3,5-disubstituted Delta2-isoxazolines in good yields. The use of Xantphos as ligand is crucial for the transformation. The carboetherification products can be further converted to beta-hydroxy ketones in the presence of Fe powder and NH4Cl. |
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