Simulation of tumor microvasculature and microenvironment response to anti-angiogenic treatment by angiostatin and endostatin |
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Authors: | Jie Wu Zu-rong Ding Yan Cai Shi-xiong Xu Gai-ping Zhao Quan Long |
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Institution: | 1. School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiaotong University,Shanghai 200240, P. R. China 2. Department of Mechanics and Engineering Science, Fudan University,Shanghai 200433, P. R. China 3. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China 4. Brunel Institute for Bioengineering, Brunei University,Uxbridge, Middlesex, UK |
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Abstract: | The effects of anti-angiogenesis treatment by angiostatin and endostatin on normalization of tumor microvasculature and microenvironment
are investigated, based on mathematical modeling and numerical simulation of tumor anti-angiogenesis and tumor haemodynamics.
The results show that after anti-angiogenesis treatment: (i) the proliferation, growth, and branching of neo-vessels are effectively
inhibited, and the extent of vascularization in tumors is accordingly reduced. (ii) the overall blood perfusion inside of
tumor is declined, the plateau of tumor interstitial fluid pressure (IFP) is relieved, the interstitial fluid oozing out from
the tumor periphery into the surrounding normal tissue is reduced, the reduction of overall extravasation across vasculature
to tumor interstium is much less than the decreased overall blood perfusion, due to the decline of IFP, the intravasations
is remarkablely effected by the change, in some cases there are no intravasation flow appear. |
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Keywords: | solid tumor microenvironment normalization numerical simulation anti-angiogenesis |
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