Synthesis and anti-tumor activities of novel [1,2,4]triazolo[1,5-a]pyrimidines |
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Authors: | Zhao Xiang-Lin Zhao Yan-Fang Guo Shu-Chun Song Hai-Sheng Wang Ding Gong Ping |
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Institution: | School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, Liaoning, PR China. smoothdagger@126.com |
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Abstract: | A series of novel 1,2,4]triazolo1,5-a]pyrimidine derivatives has been designed and synthesized in order to find novel anti-tumor compounds. The structures of all the compounds were confirmed by IR, 1H-NMR, MS and elemental analysis. Their anti-tumor activities against cancer cell lines (HT-1080 and Bel-7402) were tested by the MTT method in vitro. Among them, compound 19 displayed the best anti-tumor activity with IC50 values of 12.3 microM and 6.1 microM against Bel-7402 and HT-1080 cell lines respectively. |
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