Synthesis,Structure and Biological Evaluation of Thiourea Derivatives as Antitumor Agents |
| |
Authors: | GUO Feng-Jiao SUN Juan ZHOU Wei ZHU Hai-Liang |
| |
Affiliation: | School of Life Sciences, Shandong University of Technology, Shandong 255049, China |
| |
Abstract: | Two substituted-3-phenylthiourea derivatives have been synthesized and characterized by elemental analysis,1H NMR,MS and single-crystal X-ray diffraction.Structural stabilization of them followed by intramolecular as well as intermolecular H-bonds makes these molecules as perfect examples in molecular recognition with self-complementary donor and acceptor units within a single molecule.The antitumor activities of compounds 1 and 2 against breast adeno carcinoma cell line MCF-7 have been evaluated by MTT method.Docking simulations have also been performed to position compounds into the telomerase active sites so as to determine their probable binding models. |
| |
Keywords: | phenylthiourea derivatives crystal structure antitumor activity docking simulation |
本文献已被 CNKI 维普 等数据库收录! |
|