| 5-溴-2-羟基苯甲醇的不对称羟基保护 |
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| 引用本文： | 郭利兵,李江涛,张海洋,蒋卫鹏,韩兆海,杨瑞娜.5-溴-2-羟基苯甲醇的不对称羟基保护[J].合成化学,2009,17(4). |
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| 作者姓名： | 郭利兵 李江涛 张海洋 蒋卫鹏 韩兆海 杨瑞娜 |
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| 作者单位： | 1. 河南省科学院,化学研究所,河南,郑州,450002
2. 濮阳惠成化工有限公司,河南,濮阳,457000 |
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| 基金项目： | 河南省科技创新杰出人才计划资助项目 |
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| 摘 要： | 采用分步法对5-溴-2-羟基苯甲醇中的不对称羟基进行了选择性保护.以2,3-二氢吡喃和氯甲醚为保护基,经两步反应得5-溴-2-甲醚氧基苯甲-2-(四氢吡喃)醚,其结构经1H NMR, IR和MS表征.
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| 关 键 词： | 5-溴-2-羟基苯甲醇 不对称羟基 羟基保护 保护基团 合成 |
Protection of Asymmetric Hydroxyl of 5-Bromo-2-hydroxyphenylmethanol |
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| GUO Li-bing,LI Jiang-tao,ZHANG Hai-yang,JIANG Wei-peng,HAN Zhao-hai,YANG Rui-na.Protection of Asymmetric Hydroxyl of 5-Bromo-2-hydroxyphenylmethanol[J].Chinese Journal of Synthetic Chemistry,2009,17(4). |
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| Authors: | GUO Li-bing LI Jiang-tao ZHANG Hai-yang JIANG Wei-peng HAN Zhao-hai YANG Rui-na |
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| Institution: | 1.Institute of Chemistry;Henan Academy of Sciences;Zhengzhou 450002;China;2.Puyang Huicheng Chemical Co.;Ltd.;Puyang 457000;China |
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| Abstract: | Selective protection of the asymmetric hydroxyl of 5-bromo-2-hydroxyphenylmethanol was investigated by method of fractional steps.5-Bromo-2-methoxylmethlbenzyl-2-(tetrahydropyran)ether was synthesized by a two-step reaction using 2,3-dihydropyran and ether chloride as a protecting group of hydroxyl.The structures were characterized by 1H NMR,IR and MS. |
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| Keywords: | 5-bromo-2-hydroxyphenylmethanol asymmetric hydroxyl protection of the hydroxyl protecting group synthesis |
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