对乙酰氨基酚在分子印迹膜修饰玻碳电极上的电化学行为及测定

以对乙酰氨基酚（PCT）为模板分子，甲基丙烯酸为功能单体，采用光引发原位聚合法在玻碳电极（GCE）表面聚合成膜，以甲醇-甲酸将模板分子洗脱，制得对乙酰氨基酚分子印迹膜修饰电极（MIP-GCE），建立了该电极直接测定PCT的分析方法。结果表明，该传感器具有较高的选择性和灵敏度，PCT浓度在5.0×10-5~1.0×10-3 mol?L-1范围内与其峰电流呈良好的线性关系，检出限为1.4×10-6 mol?L-1。应用该法测定药物中PCT的含量，在干扰物质共存情况下的回收率为96%~105%。

Electrochemical Behavior and Determination of Paracetamol at Molecular Imprinted Film Modified Glassy Carbon Electrode

Using paracetamol(PCT) as template and methylacrylic acid as functional monomer,a molecular imprinted polymer film was synthesized on the surface of glassy carbon electrode(GCE) through in-situ polymerization by UV irradiation.After the template was removed with methanol and formic acid mixture solution,a paracetamol imprinted polymer film modified glassy carbon electrode(MIP-GCE) was prepared,and a method for the determination of PCT was developed with MIP-GCE.The sensor exhibited a good selectivity and sensitivity.The calibration curve was linear in the range of 5.0×10-5-1.0×10-3 mol·L-1 with a detection limit of 1.4×10-6 mol·L-1.The method was applied in the determination of PCT in drugs,with recoveries of 96%-105%.