醇与离子液体二元双水相体系萃取盐酸多西环素

基于小分子醇双水相体系和离子液体双水相体系,建立了正丙醇与亲水性离子液体1-丁基-3-甲基咪唑四氟硼酸[Bmim]BF4和(NH4)2SO4形成的二元双水相体系萃取盐酸多西环素的新方法。考察了(NH4)2SO4含量、正丙醇用量、pH值、离子液体含量以及盐酸多西环素含量对盐酸多西环素分配行为的影响。结果表明:当醇和离子液体二元双水相体系的pH值在4.0～5.0范围内,(NH4)2SO4含量为34%,且盐酸多西环素的质量浓度在25～95 mg/L之间时,该体系对盐酸多西环素的萃取率可达90.26%～95.71%,分配系数可达62.452～149.401。

Extraction of Doxycycline Hydrochloride Using Alcohol and Ionic Liquid Binary Aqueous Two Phase System

Based on the molecular alcohol aqueous two-phase system and the ionic liquid aqueous two-phase system,the new method of using n-propanol and hydrophilic ionic liquid(1-butyl-3-methylimidazolium tetrafluoroborate,BF4) with(NH4)2SO4 binary aqueous two phase system for the extraction of doxycycline hydrochloride was developed.The influence factors on partition behaviors of doxycycline hydrochloride were studied,including concentration of(NH4)2SO4,n-propanol consumption,pH value,concentration of ionic liquid and doxycycline hydrochloride.The results showed that when using pH value of 4.0-5.0,(NH4)2SO4 concentration of 34% and doxycycline hydrochloride concentration between 25-95 mg/L,the extraction rate and distribution coefficient of doxycycline hydrochloride will be up to 90.26%-95.71% and 62.452-149.401,respectively.