| Mild synthesis of N’-aryl-N,N-dimethylformamidinium chloride by Vilsmeier-Haack reagent |
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| 作者姓名： | Ge Meng Yao Wu Sha Rui Zhang Nan Bai |
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| 作者单位： | a Faculty of Pharmacy, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China;b The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China |
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| 基金项目： | the Chinese Postdoctoral Science Foundation for financial support(No.2004036602) |
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| 摘 要： | Formamidine derivatives could be used as the building blocks for substituted heterocyclic compounds with various biological activities.N’-Aryl-N,N-dimethylformamidinium chlorides have been synthesized in high yields by reaction of aromatic primary amines with Vilsmeier-Haack reagent at room temperature.The structures of all the new compounds were identified by ESI-MS,IR and NMR spectra.The steric structures of some of these compounds were clarified by X-ray single crystal analysis.
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| 关 键 词： | Vilsmeier-Haack reagent Formamidinium X-ray single crystal |
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