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| Penta-coordinate phosphorous compounds and biochemistry | |
| 引用本文： | 林长学,李艳梅,成昌梅,韩波,万荣,冯亚兵,赵玉芬. Penta-coordinate phosphorous compounds and biochemistry[J]. 中国科学B辑(英文版), 2002, 45(4): 337-348. DOI: 10.1007/BF02879344 |
| 作者姓名： | 林长学 李艳梅 成昌梅 韩波 万荣 冯亚兵 赵玉芬 |
| 作者单位： | LIN Changxue LI Yanmei CHENG ChangmeiHAN Bo WAN Rong FENG Yabing& ZHAO YufenKey Laboratory of Bioorganic Phosphorus Chemistry，Ministry of Education，Department of Chemistry，School of Life Sciences and Engineering，Tsinghua University，B |
| 基金项目： | This work was supported by the National Natural Science Foundation of China (Grant Nos. 20132020 and 20175026). |
| 摘 要： | The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to O migration occur at room temperature when the amino group of amino acid is associated with phosphoryl group. Serine or threonine in conjugate of nucleo-side-amino acid could recognize different nucleobases. N-phosphoryl Histine and Ser-His dipep-tide could cleavage nucleic acid, protein and ester in neutral medium. It is found that the above phenomena all undergo penta-coordinate intermediate of phosphorus atom, which is proposed as the key factor to determine their activities. |
Penta-coordinate phosphorous compounds and biochemistry |
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| Changxue Lin, Yanmei Li, Changmei Cheng, Bo Han, Rong Wan, Yabing Feng and Yufen Zhao. Penta-coordinate phosphorous compounds and biochemistry[J]. Science in China(Chemistry), 2002, 45(4): 337-348. DOI: 10.1007/BF02879344 | |
| Authors: | Changxue Lin Yanmei Li Changmei Cheng Bo Han Rong Wan Yabing Feng Yufen Zhao |
| Affiliation: | 1. Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China 2. Department of Chemistry, Xiamen University, Xiamen 361005, China 3. Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China;Department of Chemistry, Xiamen University, Xiamen 361005, China |
| Abstract: | The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to O migration occur at room temperature when the amino group of amino acid is associated with phosphoryl group. Serine or threonine in conjugate of nucleo-side-amino acid could recognize different nucleobases. N-phosphoryl Histine and Ser-His dipep-tide could cleavage nucleic acid, protein and ester in neutral medium. It is found that the above phenomena all undergo penta-coordinate intermediate of phosphorus atom, which is proposed as the key factor to determine their activities. |
| Keywords: | penta-coordlnate phosphorus compounds biochemistry nucleotide amino add origin of life. |
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