| Laser flash photolysis and pulse radiolysis study on chemical activity of VP-16 and podophyllotoxin |
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| 作者姓名： | 孙晓宇 张超杰 王玫 汪世龙 倪亚明 姚思德 |
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| 作者单位： | SUN Xiaoyu，ZHANG Chaojie，WANG MeiWANG Shilong，Nl Yaming & YAO SideAnalysis and Research Center of Tongji University，Shanghai 200092，China;Laboratory of Radiation Chemistry，Shanghai Institute of Nuclear Research，Chinese Academy of Sciences，Shangha |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China (Grant No. 39700029). |
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| 摘 要： | Time-resolved laser flash photolysis and pulse radiolysis have been used to study the chemical activity of podophyllotoxin(PPT) and etoposide(VP-16). The mechanism of photoioniza-tion of etoposide and podophyllotoxin has been confirmed and illustrated. It is demonstrated that VP-16 and PPT in aqueous solution can be photoionized at 248 nm to give hydrated electron and neutral radical resulting from rapid deprotonation of radical cation of VP-16 and PPT. The quantum yield for the photoionization of VP-16 and PPT with single-photo is 0.21 and 0.61, respectively. In addition, they can react with hydrated electron, hydrogen radical and hydroxyl radical. This will give chemists some advice on synthesizing new derivatives of podophyllotoxin in cancer treatment.
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| 收稿时间： | 11 October 2010 |
Laser flash photolysis and pulse radiolysis study on chemical activity of VP-16 and podophyllotoxin |
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| Xiaoyu Sun, Chaojie Zhang, Mei Wang, Shilong Wang, Yaming Ni and Side Yao.Laser flash photolysis and pulse radiolysis study on chemical activity of VP-16 and podophyllotoxin[J].Science in China(Chemistry),2002,45(2):191-199. |
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| Authors: | Xiaoyu Sun Chaojie Zhang Mei Wang Shilong Wang Yaming Ni and Side Yao |
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| Institution: | 1. Analysis and Research Center of Tongji University, Shanghai 200092, China
2. Laboratory of Radiation Chemistry, Shanghai Institute of Nuclear Research, Chinese Academy of Sciences, Shanghai 201800, China |
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| Abstract: | Time-resolved laser flash photolysis and pulse radiolysis have been used to study the chemical activity of podophyllotoxin(PPT) and etoposide(VP-16). The mechanism of photoioniza-tion of etoposide and podophyllotoxin has been confirmed and illustrated. It is demonstrated that VP-16 and PPT in aqueous solution can be photoionized at 248 nm to give hydrated electron and neutral radical resulting from rapid deprotonation of radical cation of VP-16 and PPT. The quantum yield for the photoionization of VP-16 and PPT with single-photo is 0.21 and 0.61, respectively. In addition, they can react with hydrated electron, hydrogen radical and hydroxyl radical. This will give chemists some advice on synthesizing new derivatives of podophyllotoxin in cancer treatment. |
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| Keywords: | podophyllotoxin VP-16 laser flash photolysis pulse radiolysis antitumor activity |
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