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An efficient synthesis of isocoumarins via a CuI catalyzed cascade reaction process |
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| Authors: | LeiLei Wang XiaoJing Zhang YongWen Jiang DaWei Ma |
| Institution: | (1) Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA;(2) Department of Materials Science and Engineering, Michigan Technological University, Houghton, MI 49931, USA; |
| Abstract: | 3-Alkyl isocoumarins are provided by CuI/amino acid-catalyzed Sonogashira coupling reaction of o-bromo benzoic acids and terminal alkynes and the subsequent additive cyclization. This cascade process allows synthesis of diverse isocoumarins by varying both coupling partners bearing a wide range of functional groups. |
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