Microwave-assisted synthesis and antibacterial activity of some pyrazol-1-ylquinoxalin- 2(1H)-one derivatives |
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| Authors: | Olayinka O. Ajani Craig A. Obafemi Chinwe O. Ikpo Kehinde O. Ogunniran Obinna C. Nwinyi |
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| Affiliation: | (1) Department of Oncology, The Ninth People’s Hospital of Chongqing, Chongqing, 400700, China;(2) College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China;(3) Institutes of Organic Chemistry and Developmental Biology, Shandong University, Jinan, 250100, China;(4) Department of Chemistry, Changwon National University, Changwon, GN, 641-733, South Korea; |
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| Abstract: | 3-Hydrazinoquinoxalin-2(1H)-one was prepared from quinoxaline-2,3-dione and subsequently used for the synthesis of some potentially biologically active 3-(pyrazol-1-yl)quinoxalin-2(1H)-one derivatives. While 3-(3,5-dimethylpyrazol-1-yl)quinoxalin-2(1H)-one showed a comparative effect with streptomycin, 3-(5-oxo-3-phenyl-4,5-di- hydropyrazol-1-yl)quinoxalin-2(1H)-one was found to be the most active with an MIC value of 7.8 μg/ml. |
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