Repair of (6‐4) Lesions in DNA by (6‐4) Photolyase: 20 Years of Quest for the Photoreaction Mechanism |
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| Authors: | Junpei Yamamoto Pascal Plaza Klaus Brettel |
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| Institution: | 1. Division of Chemistry, Graduate School of Engineering Science, Osaka University, Osaka, Japan;2. Ecole Normale Supérieure, PSL Research University, UPMC Univ Paris 06, CNRS, Département de Chimie, PASTEUR, Paris, France;3. Sorbonne Universités, UPMC Univ Paris 06, ENS, CNRS, PASTEUR, Paris, France;4. Institute for Integrative Biology of the Cell (I2BC), IBITECS, CEA, CNRS, Univ Paris‐Sud, Université Paris‐Saclay, Gif‐sur‐Yvette, France |
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| Abstract: | Exposure of DNA to ultraviolet (UV) light from the Sun or from other sources causes the formation of harmful and carcinogenic crosslinks between adjacent pyrimidine nucleobases, namely cyclobutane pyrimidine dimers and pyrimidine(6–4)pyrimidone photoproducts. Nature has developed unique flavoenzymes, called DNA photolyases, that utilize blue light, that is photons of lower energy than those of the damaging light, to repair these lesions. In this review, we focus on the chemically challenging repair of the (6–4) photoproducts by (6–4) photolyase and describe the major events along the quest for the reaction mechanisms, over the 20 years since the discovery of (6‐4) photolyase. |
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