| Abstract: | This article describes a mathematical biology workshop givento secondary school teachers of the Danville area in Virginia,USA. The goal of the workshop was to enable teams of teacherswith biology and mathematics expertise to incorporate lessonplans in mathematical modelling into the curriculum. The biologicalfocus of the activities is the lactose operon in Escherichiacoli, one of the first known intracellular regulatory networks.The modelling approach utilizes Boolean networks and tools fromdiscrete mathematics for model simulation and analysis. Theworkshop structure simulated the team science approach commonin today's practice in computational molecular biology and thusrepresents a social case study in collaborative research. Theworkshop provided all the necessary background in molecularbiology and discrete mathematics required to complete the project.The activities developed in the workshop show students the valueof mathematical modelling in understanding biochemical networkmechanisms and dynamics. The use of Boolean networks, ratherthan the more common systems of differential equations, makesthe material accessible to students with a minimal mathematicalbackground. High school students can be exposed to the excitement of mathematicalbiology from both the biological and mathematical point of view.Through the development of instructional modules, high schoolbiology and mathematics courses can be joined without havingto restructure the curriculum for either subject. The relevanceof an early introduction to mathematical biology allows studentsnot only to learn curriculum material in a innovative setting,but also creates an awareness of new educational and careeropportunities that are arising from the interconnections betweenbiological and mathematical sciences. The materials used in this workshop are available at a websitecreated by the directors: http://polymath.vbi.vt.edu/mathbio2006/. |
